Journal of Immunology Research and Innovation

ABSTRACT

Leukocyte traficking is a vital process that governs the movement of white blood cells throughout the body to maintain immune surveillance, respond to infection, and resolve inflammation. This complex, multistep process involves leukocyte rolling, activation, firm adhesion, transmigration
across endothelial barriers, and interstitial migration, orchestrated by an intricate network of adhesion molecules, chemokines, and receptors. Dysregulation of leukocyte traficking is implicated in numerous pathological conditions, including autoimmune diseases, chronic inflammation, cancer, and transplant rejection. Recent advances in understanding the molecular and cellular mechanisms of leukocyte migration have led to the development of targeted therapies that modulate immune cell movement, offering promising treatment strategies. This review explores the core mechanisms and key molecules involved in leukocyte tracking, highlights disease-specific implications, and examines current and emerging therapeutic approaches that leverage this critical biological process.

KEYWORDS

1. Chemokines
2. Leukocyte traficking
3. Chronic inflammation
4. Dendritic cells
5. Lymphocytes